Table of Contents:
  • Use of the maximum tolerated dose in animal bioassays for carcinogenicity
  • Introduction
  • Correlations between carcinogenic potency and other measures of toxicity
  • Advantages and disadvantages of bioassays that use the MTD
  • Options considered
  • Conclusions and recommendations
  • Two-stage model of carcinogenesis
  • Issues in risk assessment
  • Paradigm for ecological risk assessment
  • Introduction
  • Scope of ecological risk assessment
  • Revision of 1983 framework to incorporate ecological risk assessment
  • Key scientific problems limiting application of ecological risk assessment
  • Conclusions
  • Recommendations.