Relationship between moderate intensity endurance training volume and natural killer cell cytolytic activity.
This study was designed to examine if a dose-response relationship exists between moderate intensity chronic exercise stress and murine splenic natural killer cell (NK) cytolytic activity. It was hypothesized that a threshold exists for training-induced enhancement of NK cell cytolytic activity. Fem...
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| Format: | Thesis Electronic eBook |
| Language: | English |
| Published: |
1997
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| Online Access: | Static URL is not available. In OregonPDF, search for the Author using the All tab. Static URL is not available. In OregonPDF, search for the Author using the All tab |
MARC
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| 100 | 1 | |a Lee, Eric G. | |
| 245 | 1 | 0 | |a Relationship between moderate intensity endurance training volume and natural killer cell cytolytic activity. |
| 260 | |c 1997 | ||
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| 502 | |c Washington State University |d 1997 | ||
| 520 | |a This study was designed to examine if a dose-response relationship exists between moderate intensity chronic exercise stress and murine splenic natural killer cell (NK) cytolytic activity. It was hypothesized that a threshold exists for training-induced enhancement of NK cell cytolytic activity. Female, Swiss Webster mice (n=40) were assigned to treatment groups on the basis of body weight. Treatment groups consisted of either treadmill control (TC) or treadmill trained mice. Trained mice ran at a constant speed of 12 meters/minute (8 degrees grade) for: 15 minutes (EX15), 30 minutes (EX30), or 60 minutes (EX 60) per day, five days per week for 10 weeks. NK cytolytic activity was determined by a standard (51)Cr release assay. Cytolytic activity was expressed as median lytic units (LU), median LU per AsGM-1+ cell, and median LU per spleen. NK cytolytic activity was not statistically increased by any training volume. However, the greatest increase in NK cell cytolytic activity (median LU per AsGM-1+ cell) was observed in EX30 group (p =0.1). Training volumes less than or greater than this level produced smaller increases in NK cytolytic activity. These data provide preliminary evidence supporting an inverted U shaped relationship between training volume and increased basal NK cell cytolytic activity. | ||
| 533 | |a Electronic reproduction. |b Eugene : |c Kinesiology Publications, University of Oregon. |n Mode of access: World Wide Web; requires Adobe Acrobat Reader. | ||
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