Forensic DNA typing : biology, technology, and genetics of STR markers /
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| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Burlington, MA :
Elsevier Academic Press,
c2005.
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| Edition: | 2nd ed. |
| Subjects: |
Table of Contents:
- Overview and history of DNA typing
- DNA biology review
- Sample collection, DNA extraction and DNA quantitation
- The polymerase chain reaction (DNA amplification)
- Commonly used short tandem repeat markers and commercial kits
- Biology of STRs : stutter products, non-template addition, microvariants, null alleles, and mutation rates
- Forensic issues : degraded DNA, PCR inhibition, contamination, mixed samples and low copy number
- Single nucleotide polymorphisms and other bi-allelic markers
- Y chromosome DNA testing
- Mitochondrial DNA analysis
- Non-human DNA testing and microbial forensics
- DNA separation methods : slab-gel and capillary electrophoresis
- DNA detection methods : fluorescent dyes and silver-staining
- Instrumentation for STR typing : ABI 310, ABI 3100, FMBIO systems
- STR genotyping issues
- Laboratory validation
- New technologies, automation, and expert systems
- Combined DNA index system (CODIS) and the use of DNA databases
- Basic genetic principles, statistics, and probability
- STR population database analyses
- Profile frequency estimates, likelihood ratios, and source attribution
- Approaches to statistical analysis of mixtures and degraded DNA
- Kinship and parentage testing
- Mass disaster DNA victim identification.
