Successful Drug Discovery. Volume 1 /
The first volume of the book series ""Successful Drug Discovery"" isfocusing on new drug discoveries during the last decade, fromestablished drugs to recently introduced drugs of all kinds:small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in...
Saved in:
Other Authors: | , |
---|---|
Format: | Electronic eBook |
Language: | English |
Published: |
Weinheim, Germany :
Wiley-VCH,
[2015]
|
Subjects: | |
Online Access: | CONNECT |
MARC
LEADER | 00000nam a2200000 i 4500 | ||
---|---|---|---|
001 | in00006301293 | ||
006 | m o d | ||
007 | cr cnu|||unuuu | ||
008 | 150206s2015 gw ob 001 0 eng d | ||
005 | 20240124152818.8 | ||
020 | |a 9783527678433 | ||
020 | |a 9783527678440 |q (electronic bk.) | ||
020 | |a 3527678441 |q (electronic bk.) | ||
020 | |a 3527336850 | ||
020 | |a 9783527336852 | ||
020 | |a 3527678433 | ||
020 | |z 9783527336852 | ||
035 | |a (NhCcYBP)e80fa363d91f485b9a695405a0a7a4bb9783527678433 | ||
035 | |a 1wileyeba9783527678433 | ||
040 | |a NhCcYBP |b eng |e rda |c NhCcYBP | ||
050 | 4 | |a RS420 |b .S83 2015 | |
060 | 4 | |a QV 55 | |
082 | 0 | 4 | |a 615.1/9 |2 23 |
245 | 0 | 0 | |a Successful Drug Discovery. |n Volume 1 / |c edited by János Fischer and David P. Rotella. |
264 | 1 | |a Weinheim, Germany : |b Wiley-VCH, |c [2015] | |
300 | |a 1 online resource | ||
336 | |a text |b txt |2 rdacontent | ||
337 | |a computer |b c |2 rdamedia | ||
338 | |a online resource |b cr |2 rdacarrier | ||
500 | |a Wiley EBA |5 TMurS | ||
588 | 0 | |a Vendor-supplied metadata. | |
504 | |a Includes bibliographical references and index. | ||
505 | 0 | |a Cover; Related Titles; Title Page; Copyright; Advisory Board Members; Preface; Part I: General Aspects; Part II: Drug Class; Part III: Case Histories; Chapter 1: Serendipitous Target-Based Drug Discoveries; 1.1 Introduction; 1.2 Recent Examples of Target-Based Drug Discovery; 1.3 Serendipitous Target-Based Drug Discoveries; 1.4 Drospirenone (Contraceptive with Anti-aldosterone Activity); 1.5 Escitalopram (Selective Serotonin Reuptake Inhibitor Antidepressant); 1.6 Ezetimibe (Inhibitor of Cholesterol Absorption); 1.7 Lamotrigine (Discovery of a Standalone Drug for the Treatment of Epilepsy). | |
505 | 8 | |a 1.8 Omeprazole (Proton Pump Inhibitor Acid-Suppressive Agent)1.9 Outlook; Acknowledgments; List of Abbreviations; References; Chapter 2: Drug Discoveries and Molecular Mechanism of Action; 2.1 Introduction; 2.2 Mechanistic Paradox; 2.3 Molecular Mechanism of Action; 2.4 How MMOAs were Discovered; 2.5 Case Study: Artemisinin; 2.6 Summary; List of Abbreviations; References; Chapter 3: Insulin Analogs -- Improving the Therapy of Diabetes; 3.1 Introduction; 3.2 Pharmacology and Insulin Analogs; 3.3 Chemical Description; 3.4 Rapid-Acting Insulin Analogs (Prandial or Bolus Insulin). | |
505 | 8 | |a 3.5 Long-Acting Insulin Analog Formulations (Basal Insulin)3.6 Conclusions and Future Considerations; List of Abbreviations; References; Chapter 4: The Discovery of StendraTM (Avanafil) for the Treatment of Erectile Dysfunction; 4.1 Introduction; 4.2 Discovery of Avanafil; 4.3 Pharmacological Features of Avanafil; 4.4 Clinical Studies of Avanafil; 4.5 Conclusion; List of Abbreviations; References; Chapter 5: Dapagliflozin, A Selective SGLT2 Inhibitor for Treatment of Diabetes; 5.1 Introduction; 5.2 Role of SGLT2 Transporters in Renal Function; 5.3 O-Glucoside SGLT2 Inhibitors. | |
505 | 8 | |a 5.4 m-Diarylmethane C-Glucosides5.5 Profiling Studies with Dapagliflozin; 5.6 Clinical Studies with Dapagliflozin; 5.7 Summary; List of Abbreviations; References; Chapter 6: Elvitegravir, A New HIV-1 Integrase Inhibitor for Antiretroviral Therapy; 6.1 Introduction; 6.2 Discovery of Elvitegravir; 6.3 Conclusion; List of Abbreviations; References; Chapter 7: Discovery of Linagliptin for the Treatment of Type 2 Diabetes Mellitus; 7.1 Introduction; 7.2 Discovery of Linagliptin -- High Throughput Screening Hit Optimization. | |
505 | 8 | |a 7.3 Rationalization of DPP-4 Inhibition Potency by Crystal Structure Analysis and Studies of Binding Kinetics7.4 Basic Physicochemical, Pharmacological, and Kinetic Characteristics; 7.5 Preclinical Studies; 7.6 Clinical Studies; 7.7 Conclusion; List of Abbreviations; References; Chapter 8: The Discovery of Alimta (Pemetrexed); List of Abbreviations; References; Chapter 9: Perampanel: A Novel, Noncompetitive AMPA Receptor Antagonist for the Treatment of Epilepsy; 9.1 Introduction; 9.2 Seeds Identification by High Throughput Screening (HTS) Assays. | |
520 | |a The first volume of the book series ""Successful Drug Discovery"" isfocusing on new drug discoveries during the last decade, fromestablished drugs to recently introduced drugs of all kinds:small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in some very successful drugswhere the research targets of the lead molecule and the drug aredifferent. Phenotypic and target-based drug discovery approachesare discussed from the viewpoint of pioneer drugs and analogues. This volume gives an excellent overview of insulin analoguesincluding a discussion of the properties of | ||
650 | 0 | |a Drugs |x Design. | |
650 | 0 | |a Pharmaceutical chemistry. | |
650 | 0 | |a Designer drugs. | |
650 | 2 | |a Designer Drugs | |
650 | 2 | |a Drug Design | |
650 | 2 | |a Chemistry, Pharmaceutical | |
700 | 1 | |a Fischer, János, |e editor. | |
700 | 1 | |a Rotella, David P., |e editor. | |
730 | 0 | |a WILEYEBA | |
776 | 0 | 8 | |i Print version: |t Successful drug discovery. Volume 1. |d Weinheim, [Germany] : Wiley-VCH Verlag, ©2015 |h xi, 235 pages |z 9783527336852 |
856 | 4 | 0 | |u https://ezproxy.mtsu.edu/login?url=https://onlinelibrary.wiley.com/book/10.1002/9783527678433 |z CONNECT |3 Wiley |t 0 |
949 | |a ho0 | ||
975 | |p Wiley UBCM Online Book All Titles thru 2023 | ||
976 | |a 6006612 | ||
998 | |a wi |d z | ||
999 | f | f | |s 4cbf7f38-9e40-4b0f-8df0-60904a3e18f5 |i 9ff8100b-ce1b-4938-8990-cf6862bf7c92 |t 0 |
952 | f | f | |a Middle Tennessee State University |b Main |c James E. Walker Library |d Electronic Resources |t 0 |e RS420 .S83 2015 |h Library of Congress classification |