Pharmacokinetic optimization in drug research : biological, physicochemical, and computational strategies /
The optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. There was, hence, an urgent need for a book covering this field in an authoritative, comprehensive, factual, and conceptual manner. In this work of unique breadth and depth, international...
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| Format: | Electronic Conference Proceeding eBook |
| Language: | English |
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Zürich : Weinheim ; New York :
Verlag Helvetica Chimica Acta ; Wiley-VCH,
©2001.
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| Online Access: | CONNECT |
| Summary: | The optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. There was, hence, an urgent need for a book covering this field in an authoritative, comprehensive, factual, and conceptual manner. In this work of unique breadth and depth, international authorities and practicing experts from academia and industry present the most modern biological, physicochemical, and computational strategies to achieve optimal pharmacokinetic properties in research series. These properties include gastrointestinal absorption, protein binding, brain permeation, and metabolic profile. Toxicological issues are, of course, also of utmost importance. In addition to its 33 chapters, the book includes a CD-ROM containing the invited lectures, oral communications and posters (in full version) presented at the Second LogP Symposium, 'Lipophilicity in Drug Disposition -- Practical and Computational Approaches to Molecular Properties Related to Drug Permeation, Disposition and Metabolism', held at the University of Lausanne in March 2000.n̓. |
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| Item Description: | Wiley EBA |
| Physical Description: | 1 online resource (x, 655 pages : : illustrations.) |
| Bibliography: | Includes bibliographical references and index. |
| ISBN: | 9783906390437 3906390438 (electronic bk.) |
