NMR spectroscopy in drug development and analysis /

Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds. In the 1980s, the high-resolution NMR spectrometer (& 300 Mhz) and 2D experiments were introduced, which opens up the...

Full description

Saved in:
Bibliographic Details
Main Author: Holzgrabe, U.
Other Authors: Wawer, I., Diehl, B.
Format: Electronic eBook
Language:English
Published: Weinheim ; New York ; Chichester : Wiley-VCH, ©1999.
Subjects:
Online Access:CONNECT

MARC

LEADER 00000nam a2200000 a 4500
001 in00006299486
006 m o d
007 cr un||||a|a||
008 100723s1999 enka ob 001 0 eng d
005 20240124152640.2
020 |a 9783527613649 
020 |a 9783527613656  |q (electronic bk.) 
020 |a 352761365X  |q (electronic bk.) 
020 |a 3527613641 
020 |z 3527300929 
020 |z 9783527300921 
024 7 |a 10.1002/9783527613649  |2 doi 
035 |a (NhCcYBP)e80fa363d91f485b9a695405a0a7a4bb9783527613649 
035 |a 1wileyeba9783527613649 
037 |a 10.1002/9783527613649  |b Wiley InterScience  |n http://www3.interscience.wiley.com 
040 |a NhCcYBP  |b eng  |c NhCcYBP 
042 |a dlr 
050 4 |a RM301.25  |b .H65 1999 
060 4 |a 2000 E-877 
060 4 |a QV 744  |b H762n 1999 
082 0 4 |a 615.19  |2 21 
084 |a VG 9500  |2 rvk 
084 |a CHE 808f  |2 stub 
084 |a CHE 244f  |2 stub 
084 |a CIT 840f  |2 stub 
100 1 |a Holzgrabe, U.  |q (Ulrike) 
245 1 0 |a NMR spectroscopy in drug development and analysis /  |c U. Holzgrabe, I. Wawer, B. Diehl. 
260 |a Weinheim ;  |a New York ;  |a Chichester :  |b Wiley-VCH,  |c ©1999. 
300 |a 1 online resource (299 pages) :  |b illustrations 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
500 |a Wiley EBA  |5 TMurS 
504 |a Includes bibliographical references and index. 
505 0 |a NMR spectroscopy in the European regulatory dossier / S. Branch -- Analysis of drugs / B.W.K. Diehl and U. Holzgrabe -- pH-dependent NMR measurements / G. Hägele and U. Holzgrabe -- Complexation behaviour of drugs studied by NMR / B.W.K. Diehl and U. Holzgrabe -- Determination of the isometric composition of drugs / B.W.K. Diehl and U. Holzgrabe -- On-line coupling of HPLC or SFC / K. Albert -- NMR of body fluids / U. Holzgrabe -- NMR as a tool in drug research / G. Gemmecker -- Ligand-cyclodextrin complexes / B. Chankvetadze, G. Blaschke and G. Pintore -- Ligand-membrane interaction / J.K. Seydel -- Solid-state NMR in drug analysis / I. Wawer -- MR imaging and MR spectroscopy / I. Wawer. 
520 |a Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds. In the 1980s, the high-resolution NMR spectrometer (& 300 Mhz) and 2D experiments were introduced, which opens up the possibility to determine the 3D structure of large molecules, especially biomolecules. However, NMR spectroscopy has been rarely applied to drug analysis. This book illustrates the power and versatility of NMR spectroscopy in the determination of impurities in and the content of drugs, the composition o. 
533 |a Electronic reproduction.  |b [Place of publication not identified] :  |c HathiTrust Digital Library,  |d 2010.  |5 MiAaHDL 
588 0 |a Print version record. 
650 0 |a Drug development. 
650 0 |a Drugs  |x Analysis. 
650 0 |a Nuclear magnetic resonance spectroscopy. 
650 0 |a Pharmaceutical chemistry. 
650 0 |a Drugs  |x Design. 
650 2 |a Chemistry, Pharmaceutical 
650 2 |a Drug Design 
650 2 |a Magnetic Resonance Spectroscopy 
700 1 |a Wawer, I.  |q (Iwona) 
700 1 |a Diehl, B.  |q (Bernd) 
730 0 |a WILEYEBA 
776 0 8 |i Print version:  |a Holzgrabe, U. (Ulrike).  |t NMR spectroscopy in drug development and analysis.  |d Weinheim ; New York ; Chichester : Wiley-VCH, ©1999 
856 4 0 |u https://ezproxy.mtsu.edu/login?url=https://onlinelibrary.wiley.com/book/10.1002/9783527613649  |z CONNECT  |3 Wiley  |t 0 
949 |a ho0 
975 |p Wiley UBCM Online Book All Titles thru 2023 
976 |a 6006612 
998 |a wi  |d z 
999 f f |s 99ef15b6-18f1-4965-9e7e-f514dcb06b5e  |i 9c986b4f-fea4-473f-b0fa-759fbfc3872d  |t 0 
952 f f |a Middle Tennessee State University  |b Main  |c James E. Walker Library  |d Electronic Resources  |t 0  |e RM301.25 .H65 1999  |h Library of Congress classification