Immunotoxicology strategies for pharmaceutical safety assessment /
An important resource for toxicologists in pharmaceutical and biotechnology areas, this book discusses recently introduced systems for immunotoxicology testing and their applications. Immunotoxicology pharmaceutical safety assessments are important for streamlining the development process and reduci...
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| Other Authors: | , |
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
Hoboken, N.J. :
Wiley,
©2008.
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| Subjects: | |
| Online Access: | CONNECT |
Table of Contents:
- Current regulatory expectations for immunotoxicologyy evaluation of pharmaceuticals / Kenneth L. Hastings
- Clinical pathology as crucial insight into immunotoxicity testing / Ellen Evans
- Histomorphology of the immune system : a basic step in assessing immunotoxicity / Patrick Haley.
- Need for specialized immunotoxicity tests / Kazuichi Nakamura
- Specific drug-induced immunotoxicity : immune-mediated hemolytic anemia / Raj Krishnaraj
- T cell-dependent antibody response tests / Joseph R. Piccotti
- Natural killer cell assay and other innate immunity tests / Lisa Plitnick
- Cellular immune response in delayed-type hypersensitivity test / Karen Price
- Evaluation of drug effects on immune cell phenotypes / Laurie Iciek.
- Functional cellular responses and cytokine profiles / Elizabeth R. Gore
- Application of flow cytometry in drug development / Padma Narayanan [and others]
- Animal models of host resistance / Gary R. Burleson and Florence G. Burleson
- Approaches to evaluation of autoimmunity / Danuta J. Herzyk.
- Differentiating between desired immunomodulation and potential immunotoxicity / Jeanine L. Bussiere and Barbara Mounho
- Relevant immune tests across different species and surrogate models / Jeanine L. Bussiere
- Antidrug antibody responses in nonclinical studies and their implications / Barbara Mounho
- Pharmacological immunogenicity and adverse responses to vaccines / Mary Kate Hart, Mark Bolanowski, and Robert V. House.
- Immunotoxicological concerns for vaccines and adjuvants / Catherine Kaplanski [and others]
- Systemic hypersensitivity / Raymond Pieters
- Nonclinical models to assess respiratory hypersensitivity potential / Curtis C. Maier
- Developmental immunotoxicity in rodents / Rodney R. Dietert and Leigh Ann Burns-Naas
- Developmental immunotoxicity in nonhuman primates / Pauline L. Martin and Eberhard Buse.
- Alternative animal models for immunomodulation and immunotoxicity / Peter J. Bugelski
- Animal models for preclinical comparative immunogenicity testing / Daniel Wierda
- T cell epitopes and minimization of immunogenicity / Harald Kropshoffer and Thomas Singer
- Bridging immunotoxicology to clinical drug development / Ian Gourley and Jacques Descotes.
