Cellular signal transduction in toxicology and pharmacology : data collection, analysis, and interpretation /
Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug...
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| Other Authors: | , |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Hoboken, NJ :
Wiley,
2019.
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| Edition: | First edition. |
| Subjects: | |
| Online Access: | CONNECT |
Table of Contents:
- Intro; Title Page; Copyright Page; Contents; List of Contributors; About the Editors; Preface; Chapter 1 Introduction to Cellular Signal Transduction: The Connection Between a Biological System and Its Surroundings; 1.1 Starting Big, but Ending Small; 1.1.1 Key Features of Signal Transduction; 1.2 Responding to Our Environment: Sensory Perception Begins and Ends with Signal Transduction; 1.2.1 Taste (Gustation); 1.2.2 Smell (Olfaction); 1.2.3 Sight (Vision); 1.2.4 Sound (Audition); 1.2.5 Touch (Somatosensation); 1.3 Primary Transport Systems Involved in Signal Transduction
- 1.3.1 Ion Channels, Transporters, and Ion Pumps1.3.2 Receptors; 1.3.3 Endocytosis; 1.3.4 Exosomes; 1.4 Key Organelles Involved in Signal Transduction; 1.4.1 Mitochondria; 1.4.2 Endoplasmic Reticulum; 1.4.3 Nucleus; References; Chapter 2 Mechanisms of Cellular Signal Transduction; 2.1 Posttranslational Modifications and Their Roles in Signal Transduction; 2.1.1 Phosphorylation; 2.1.2 Acylation; 2.1.3 Alkylation; 2.1.4 Glycosylation; 2.1.5 Other PTMs; 2.2 Receptors; 2.3 Receptor Signaling Mechanisms; 2.3.1 Basic Principles of Signal Transduction Mechanisms; 2.3.1.1 Selectivity and Recognition
- 2.3.1.2 Flexible Modularity2.3.1.3 Molecular Switches; 2.3.1.4 GPCRs and Second Messengers; 2.3.1.5 Amplification; 2.3.1.6 Turn-Off Mechanisms; 2.3.1.7 Localization; 2.3.1.8 Biased Signaling/Functional Selectivity; 2.4 Receptor Tyrosine Kinases; 2.5 Steroid Receptors; 2.6 Reactive Oxygen Species (ROS); 2.7 Summary; References; Chapter 3 From Cellular Mechanisms to Physiological Responses: Functional Signal Integration Across Multiple Biological Levels; 3.1 Introduction; 3.2 Cellular Information Flow: Mechanisms of Cellular Signal Integration and Regulation
